Preprints

Abstract: We propose a statistical framework to integrate radiological magnetic resonance imaging (MRI) and genomic data to identify the underlying radiogenomic associations in lower grade gliomas (LGG). We devise a novel imaging phenotype by dividing the tumor region into concentric spherical layers that mimics the tumor evolution process. MRI data within each layer is represented by voxel–intensity-based probability density functions which capture the complete information about tumor heterogeneity. Under a Riemannian-geometric framework these densities are mapped to a vector of principal component scores which act as imaging phenotypes.

Abstract: Tweedie exponential dispersion family constitutes a fairly rich sub-class of the celebrated exponential family. In particular, a member, compound Poisson gamma (CP-g) model has seen extensive use over the past decade for modeling mixed response featuring exact zeros with a continuous response from a gamma distribution. This paper proposes a framework to perform residual analysis on CP-g double generalized linear models for spatial uncertainty quantification. Approximations are introduced to proposed framework making the procedure scalable, without compromise in accuracy of estimation and model complexity; accompanied by sensitivity analysis to model mis-specification.