IEEE Engineering in Medicine and Biology Society (EMBS) Annual International Conference (EMBC) Proceedings (2023).
Discrimination of pseudoprogression and true progression is challenging in malignant gliomas. We investigate low‑parametric supervised learning (geographically weighted regression; GWR) on widely available MRI modalities—including ADC—to distinguish pseudoprogression from true progression. Applying GWR to modality pairs is suitable for small samples and novel in this setting. Modality pairs involving ADC and those regressing post‑contrast T1 onto T2 showed promise. Results suggest the predictive benefit of ADC and motivate further study of relationships between post‑contrast T1 and T2.